Aluminum chloride hexahydrate, tested according to Ph.Eur. Simultaneous administration of propolis attenuated the increased numbers of micronucleated hepatocytes induced by aluminium chloride.
77, No. A 100-ml flask, A, contains a solution of electrolytes and some excess salt. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. 3 0 obj<>stream
Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. A positive result was reported for two out of six bacterial strains (S. typhimurium TA 100 and 98) with and without metabolic activation. Clinical signs or body weights were not reported, which makes an evaluation of whether the MTD has been met or exceeded impossible. the enzymatic activities of ALP, AST, ALT and LDH, and the levels of urea and uric acid significantly increased. However, this study was conducted in non-GLP conditions and without standard methodology. Cytotoxicity was indirectly measured by apoptosis. CopyCopied, InChI=1S/Al.3ClH.6H2O/h;3*1H;6*1H2/q+3;;;;;;;;;/p-3
1 gm of aluminum chloride hexahydrate dissolves in 0.9 ml water and 4 ml of alcohol. In addition, haematological, biochemical parameters and histological alterations in liver and kidney were investigated. Incompatible with acids.Note that decomposition of the anhydrous product, possibly caused by moisture leakinginto the container or being
Although the study was not specified as GLP-compliant, it is well documented and was performed according to a peer reviewed protocol developed during the International Workshop on Genotoxicity Test Procedures. Four mice were used for each fixation interval. Therefore, the study was disregarded. Solubility table From Wikipedia, the free encyclopedia See also: Solubility chart The table below provides information on the variation of solubility of different substances (mostly inorganic compounds) in water with temperature, under 1 atm pressure, units of solubility in g/100g H2O. reported a bacterial reverse mutation assay using S. typhimurium strains TA 98, 100, 1535, 1537, 1538 and the E. coli WP2 uvrA strain. (1982) reported limited information from an in vitro mammalian cell gene mutation assay. Test concentrations used were between 20 - 5000 ug/plate. . Therefore, the study was disregarded. All Rights Reserved. The data of the treated series showed that the chromatid type breaks, gaps and constrictions were regular in occurrence while the chromosome type break was very rare. Systemic bioavailability of the administered test substance was demonstrated by clinical signs (reduced spontaneous activity). ALUMINIUM CHLORIDE-6-HYDRATE EXTRA PURE, DAC, U.S.P. The study has several severe deficiencies making it unreliable: Positive control results were originally not reported and only delivered upon request, and no historical control data are reported. treated up to 2000 mg/kg/day (the maximum recommended dose for this study). It is also soluble in glycerol, ether and propylene glycol. Basic aluminium chloride was tested in a GLP-compliant, Basic aluminium chloride was also tested in a GLP-compliant. In the study, a. luminium chloride induced a statistically significant increase in the numbers of micronucleated hepatocytes. Store at +15°C to +25°C. 1 gm of aluminum chloride hexahydrate dissolves in 0.9 ml water and 4 ml of alcohol. A valid Ames assay conducted in accordance with GLP and OECD guideline 471 was performed by BASF. Lot and Batch Numbers can be found on a product's label The authors report a significant increase in the number of MN in all treated groups. The potential of dialuminium chloride pentahydroxide to cause micronuclei in vivo was evaluated in a GLP-compliant in vivo micronucleus assay conducted according to OECD TG 474 (Stammberger, 1999) in mice treated up to 2000 mg/kg/day (the maximum recommended dose for this study). The study basically showed the same limitations as the Turkez study and was disregarded for the same reasons. The data of 8 and 48 h were disregarded because of the inadequate figures; the frequency of total aberration remained more or less the same at different intervals between 4 and 72 h. Tissue fixed at one hour after the treatment had also a good number of chromosomal aberrations. | Privacy. EC number: 231-208-1 | CAS number: 7446-70-0. All in all, it is very likely that the observed effects are not related to test substance exposure but were present in all animals (from treated and control groups) already before substance administration. These studies were, nonetheless, included in the dossier and are listed in the following paragraphs: JETOC (1996) reported a bacterial reverse mutation assay using S. typhimurium strains TA 98, 100, 1535, 1537, 1538 and the E. coli WP2 uvrA strain. At the end of the experiment, rats were sacrificed and hepatocytes (HEP) were isolated for counting the number of micronucleated hepatocytes (MNHEPs). If your %verypdf.com On top of that, cytotoxicity was not assessed and no positive control was used. However, the reliability of the study is considered to be low since the results were not reported in the form of a comprehensive study and only two replicates per concentration were tested, which significantly decreases the statistical power of the assay. Structure, properties, spectra, suppliers and links for: Aluminium chloride hexahydrate, 7784-13-6. Histopathology was not performed or not reported for the negative control group, so it is not possible to compare the treated and untreated groups. In the 0.1 M series, the aberration types would not show regularity in their increase or decrease at different fixation intervals. identifies anhydrous aluminium chloride and not the hexahydrate). Rats were orally administered the test substance at 34 mg/kg bw/day for 30 days. However, the use of higher concentration of AlCl3, no doubt, increased the aberration frequency to some extent. Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice. Aluminum Chloride Hexahydrate Safety Data Sheet according to Federal Register / Vol. Simultaneous administration of propolis attenuated the increased numbers of micronucleated hepatocytes induced by aluminium chloride. Particle size distribution (Granulometry), Solubility in organic solvents / fat solubility, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Biodegradation in water and sediment: simulation tests, Additional information on environmental fate and behaviour, Short-term toxicity to aquatic invertebrates, Long-term toxicity to aquatic invertebrates, Toxicity to aquatic algae and cyanobacteria, Toxicity to aquatic plants other than algae, Endocrine disrupter testing in aquatic vertebrates – in vivo, Toxicity to soil macroorganisms except arthropods, Endocrine disrupter mammalian screening – in vivo (level 3), Direct observations: clinical cases, poisoning incidents and other, Exposure related observations in humans: other data, Registrants / Suppliers - Ceased manufacture, Registration numbers - Ceased manufacture, Additional physico-chemical properties of nanomaterials, Toxicokinetics, metabolism and distribution, IPAGSA, Sant Jordi, 08191, Rubí, Barcelona, Spain. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Therefore, the study was disregarded. Reproduction of any materials from the site is strictly forbidden without permission. The increase in DNA damage and apoptotic cells (cytotoxicity) was well correlated which means that the DNA damage seen could simply be a side-effect of cytotoxicity. However, this study was diregarded because of the following main limitations: Significant damage in the liver was reported (increase in levels of serum enzymes and histological alterations in liver) whereas in a GLP OECD guideline 422 study on AlCl basic (CAS 1327-41-9), no liver damage and reduced ALP activity were observed up to 1000 mg/kg/day. Manna et al. Sodium citrate-acetic acid alcohol - air drying - Giemsa staining methodology was followed for the preparations of bone marrow cells.