CsF is commercially available – on a lab scale it costs around $50 per 100g ( Synquest), cheaper than RbF. It is harmful if inhaled or swallowed. Due to the strength of the Si-F bond, fluoride ion is useful for desilylation reactions (removal of Si groups) in organic chemistry; caesium fluoride is an excellent source of anhydrous fluoride for such reactions (see uses below). For this reason it is often used as the windows of cells used for infrared spectroscopy. 1) Patent Reference: WO2011017578, page 129, (8.3 MB), 3) www.sigmaaldrich.com: Cesium fluoride (link), 4) Reich, H. J.; Rigby, J. H.; Handbook of Reagents for Organic Synthesis, Acidic and Basic Reagents. Removal of silicon groups (desilylation) is a major application for CsF in the laboratory, as its anhydrous nature allows clean formation of water-sensitive intermediates. Base for palladium catalyzed reactions (ex. : 13400-13-0 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratorychemicals, Industrial & for professional use only. In addition, as cesium fluoride is applicable to take off containing… Cesium Fluoride. Completion fluids assist the emplacemen… It is a versatile base in organic synthesis and can be used in e.g. It is available in anhydrous form, and if water has been absorbed it is easy to dry by heating at 100 ° C for two hours in vacuo. Bruce P. Branchaud. University of Oregon, Eugene, OR, USA. It is available in anhydrous form, and if water has been absorbed it is easy to dry by heating at 100 °C for two hours in vacuo. There is a newer version of this article Gregory K. Friestad. in polymerization reactions or in brazing fluxes. Cesium fluoride (CsF) is a hygroscopic solid. It is more soluble and more readily dissociated than sodium fluoride or potassium fluoride. //]]>. Search for more papers by this author. Caesium fluoride is a useful base in organic chemistry, due the fact that fluoride ion is largely unreactive as a nucleophile. Caesium fluoride can be used in organic synthesis as a source of the fluoride anion. Cesium fluoride is less hygroscopic than other sources of highly dissociated fluorine such as TBAF. A universal cesium fluoride catalyzed procedure for nucleophilic trifluoromethylation was developed. It’s also added to dental products and some water sources to help strengthen teeth and prevent cavities. Being highly dissociated it is quite reactive as a fluoride source under anhydrous conditions too, and it will react with electron-deficient aryl chlorides to form aryl fluorides ( halex reaction). It is therefore a useful, less hygroscopic alternative to tetra-n-butylammonium fluoride (TBAF) and TAS-fluoride (TASF) when anhydrous "naked" fluoride ion is needed. • A reagent for the nucleophilic fluorination of primary halides and sulfonates in protic media such as tert -butyl and tert -pentyl alcohols. The moderately basic nature of fluorine also makes it useful as a base in certain reactions, especially when a non-nucleophilic base is desired. The largest present-day use of nonradioactive caesium is in caesium formate drilling fluids for the extractive oil industry. Caesium fluoride in THF or DMF can attack a wide variety of organosilicon compounds to produce an organosilicon fluoride and a carbanion, which can then react with electrophiles, for example: Desilylation is also useful for the removal of silyl protecting groups. Product name : Cesium Fluoride CAS-No. Cesium Fluoride. At room temperature (25 °C), with catalytic amounts of cesium fluoride, carboxylic esters were found to react to give the silyl ether intermediates, which afforded the trifluoromethyl ketones after hydrolysis.