At present there are 15 known isoforms of CA, which differ in kinetic properties, susceptibility to inhibitors, and specific tissue distribution. Department of Pediatrics, University of Rochester School of Medicine, Rochester, New York, USA, Box 777, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester New York 14642, USA, Carbonic anhydrase (CA) catalyzes the reversible hydration of CO, Carbonic anhydrase (CA) is a zinc metalloenzyme that catalyzes the reversible hydration of CO. Expression of membrane-associated carbonic anhydrase isoforms IV, IX, XII, and XIV in the rabbit: induction of CAIV and IX during maturation. Metabolic acidosis stimulates carbonic anhydrase activity in rabbit proximal tubule and medullary collecting duct. 2013 Nov 6;2(4):94-102. doi: 10.5527/wjn.v2.i4.94. Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. In the kidney, this enzyme is thought to play a pivotal role in urinary acidification and bicarbonate reabsorption. October 10, CAII and CAIV predominate in human and rabbit kidneys; in rodent kidneys, CAXII, and CAXIV are also present. Enhancement of the catalytic properties of human carbonic anhydrase III by site-directed mutagenesis. Modulation of Ca2+-dependent anion secretion by protein kinase C in normal and cystic fibrosis pancreatic duct cells. COVID-19 is an emerging, rapidly evolving situation. Characterization of CAXV, a new GPI-anchored form of carbonic anhydrase. CAIV interacts with members of the BT family of transporters to form the extracellular component of a bicarbonate transport metabolon (, The extracellular component of a transport metabolon. Dobyan DC, Magill LS, Friedman PA, Hebert SC, Bulger RE. CAII binding to the carboxyl terminus of human AE1 (band 3) was the first report of direct interaction between CAs and members of the bicarbonate transporter (BT) family. Mitochondrial carbonic anhydrase CAVB: differences in tissue distribution and pattern of evolution from those of CAVA suggest distinct physiological roles. Copyright © 2020 Elsevier Inc. except certain content provided by third parties. Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity. Normal Fertility Requires the Expression of Carbonic Anhydrases II and IV in Sperm. I. Stop-flow kinetic studies on the native human isoenzymes B and C. Carbonic anhydrase: chemistry, physiology and inhibition. Gly-63 → Gln substitution adjacent to His-64 in rodent carbonic anhydrase IVs largely explains their reduced activity. NIH Expression of carbonic anhydrase IX in mouse tissues. Complete amino acid sequence of ovine salivary carbonic anhydrase. CAII also associates with NHE1, a ubiquitously expressed glycoprotein that protects cells from intracellular acidification by exchanging one intracellular proton for one extracellular sodium. The role of von Hippel–Lindau tumor suppressor protein and hypoxia in renal clear cell carcinoma. NBC3 is an electroneutral ethylisopropylamiloride-sensitive and di-isothiocyanatostilbene 2,2′-disulfonic acid disodium salt hydrate-insensitive sodium bicarbonate co-transporter that is expressed in heart, skeletal muscle, salivary glands, and kidney. It has been proposed that CAIX activity facilitates the acidification of extracellular milieu surrounding cancer cells by converting CO, Carbonic anhydrase inhibitor suppresses invasion of renal cancer cells, Co-expression and association of CAs with transporters markedly enhances H, Ectopic expression of CAIX in RCC may enable tumor cells to survive and proliferate in hypoxic acidic environments by facilitating H. Cloning, characterization, and chromosomal mapping of a human electroneutral Na(+)-driven Cl-HCO3 exchanger. Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1a stabilization: a role for phosphatidylinositol 3′-kinase. The cytoplasmic tail of NBC3 contains two putative CAII binding motifs LDDLM (CAB1) and LQDDDD (CAB2); however only mutation of aspartic acid residues (D. This anion exchanger is expressed in the brush border membrane of proximal tubule epithelial cells, where it may mediate chloride/formate exchange, thereby contributing to NaCl reabsorption.